Project Leaders: Anil Vachani, Louise Showe, Steven Albelda, and David Speicher)

 

We have established an infrastructure to collect tumors, blood samples, and clinical information from patients undergoing surgery for lung cancer and mesothelioma.   These samples being used in a variety of studies including:  1) prediction of recurrence after lung cancer surgery using immunohistochemical, genetic, or genomic predictors, 2) identification of key genes and proteins that differentiate squamous cell carcinomas from lung cancer or head and neck tumors, 3) identifying white blood cell gene expression profiles to diagnose lung cancer, 4) use of proteomics to identify early biomarkers of lung cancer and mesothelioma.  Funding for these projects has been provided by the Pennsylvania Department of Health.

 

Representative publications

Singhal, S., Amin, K., Kruklitis, R., DeLong, P., Friscia, M., Putt, M., Kaiser, L.R., Albelda, S.M.  Alterations in cell cycle genes in early stage lung adenocarcinoma identified by expression profiling.  Cancer Biology and Therapy, 2:291-298, 2003.

Singhal, S., Amin, K., Kruklitis, R., DeLong, P., Friscia, M., Putt, M., Kaiser, L.R.,

Singhal, S., Amin, K., Kruklitis, R., Marshall, M.B., Kucharczuk, J.C., DeLong, Litzky, L.A., Kaiser, L.R., Albelda, S.M.  Differentially expressed apoptotic genes in early stage lung adenocarcinoma predicted by expression profiling.  Cancer Biology and Therapy, 2:566-571, 2003.

Singhal, S., Vachani, A., Antin-Ozerkis, Kaiser, L.R., Albelda, S.M.  Prognostic implications of cell cycle, aopoptosis, and angiogenesis biomarkers in non-small cell lung cancer. Clin Cancer Res. 11:3974-3986, 2005.

Singhal, S., Wiewrodt, R. Malden., L., Matzie, K., Friedberg, J., Amin, K.M., Kucharczuk, Jl, Litzky, L.A., Johnson, S.W., Kaiser, L.R., Albelda, S.M.  Gene expression profiling of malignant mesothelioma.  Clin. Cancer Research, 9, 3080-3097, 2003.

Vachani, A., Nebozhyn, M., Singhal, S., Beers, M., Litzky, L., Muschel, R., Powell, C., Gaffney, P. Kaiser, L., Marron J., Showe, M.,., Albelda, S., Showe, L M.   Identification of 10 Gene Classifier for Head and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma: Towards a Distinction between Primary and Metastatic Squamous Cell Carcinoma of the Lung, Clinical Cancer Research, 13:2905-2915, 2007.

 

Cancer Genomics

Thoracic Oncology Research Laboratory